The First Room is dedicated to the exhibition of papyri and the illustration of aspects, problems, themes, and moments in the history of papyrology. The materials are displayed in five showcases.
The room also houses a small Herculaneum section, where a modern reproduction of the famous machine for unrolling the Herculaneum papyri, developed in the mid-eighteenth century by Father Scolopio Antonio Piaggio, is exhibited. The Second Room contains the Egyptology and Papyrology Library, which holds over 1500 volumes on Egyptological and papyrological subjects.
The Room also hosts two showcases: the first contains a collection of ancient pottery from the eastern Mediterranean and some modern objects found in the dump of the Archaeological Mission of the University of Michigan at Soknopaiou Nesos; in the second are displayed some objects variably connected with the world of writing. The Third Room houses the management and administration of the Museum. Behind the Museum is the Laboratory for the Reading and Restoration of papyri, equipped with a station for optical analysis.

