Already owned by one of the most important families of the city, the Palace was built in the second half of the 17th century, finding its completion only in the first decade of the following century.
The Hall and the four large rooms were frescoed by Domenico Maria Canuti, Giuseppe Maria Crespi, and Donato Creti, in a journey that spans fifty years of painting touching the main protagonists of Bolognese Baroque painting which on one hand recovers, with the link to the mature phase of Canuti, the post-Renaissance age, on the other anticipates with Crespi and Creti fully eighteenth-century developments. The rooms host a significant selection of the Zambeccari art collection, among the most important in the painting history of the city.
There are works by the leading masters of Emilian painting such as Lodovico Carracci, Guercino, Albani, and Crespi, but also Passerotti, Tiarini, Mastelletta, Franceschini, Pasinelli, and Creti. Moreover, there are high testimonies of non-regional painting schools such as the Florentine, Genoese, Venetian, and Neapolitan with works by Mattia Preti, Luca Giordano, Bernardo Strozzi, Palma the Younger, Sebastiano Ricci, and Piazzetta.

